A compendium of cytogenetic abnormalities in myelofibrosis: molecular and phenotypic correlates in 826 patients

Abstract excerpt

Among 826 patients with primary myelofibrosis (PMF) and analysable metaphases on cytogenetic studies, 352 (42·6%) had abnormal karyotype, of which 240 (68·2%) were sole aberrations and 48 (13·6%) were complex; the most frequent abnormalities were 20q- (23·3%), 13q- (18·2%), +8 (11·1%), +9 (9·9%), chromosome 1q+ (9·7%) and -7/7q- (7·1%). Phenotypic correlates included: abnormal karyotype with anaemia (P = 0·02),...

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