Article
Genetic variation in long noncoding RNAs and the risk of nonalcoholic fatty liver disease.
Oncotarget - 4 Apr 2017
Sookoian Silvia, Rohr Cristian, Salatino Adrián, Dopazo Hernán, Fernandez Gianotti Tomas, Castaño Gustavo O, Pirola Carlos J
Abstract excerpt
The human transcriptome comprises a myriad of non protein-coding RNA species, including long noncoding RNAs (lncRNAs), which have a remarkable role in transcriptional and epigenetic regulation. We hypothesized that variants in lncRNAs influence the susceptibility to nonalcoholic fatty liver disease (NAFLD). Using next generation sequencing, we performed a survey of genetic variation associated with randomly...
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