Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular modeling in the age of clinical genomics, the enterprise of the next generation.

Journal of molecular modeling - 1 Mar 2017

Prokop Jeremy W, Lazar Jozef, Crapitto Gabrielle, Smith D Casey, Worthey Elizabeth A, Jacob Howard J

Abstract excerpt

Protein modeling and molecular dynamics hold a unique toolset to aide in the characterization of clinical variants that may result in disease. Not only do these techniques offer the ability to study under characterized proteins, but they do this with the speed that is needed for time-sensitive clinical cases. In this paper we retrospectively study a clinical variant in the XIAP protein, C203Y, while addressing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Apoptosis
Share to Caspase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystic Fibrosis Transmembrane Conductance Regulator

Share to Genome, Human

Share to Molecular Dynamics Simulation

Share to Nod2 Signaling Adaptor Protein

Share to X-Linked Inhibitor of Apoptosis Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 28204942
DOI: 10.1007/s00894-017-3258-3
PMCID: PMC5529140

Genes

XIAP
NOD2
CFTR
RIPK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular modeling in the age of clinical genomics, the enterprise of the next generation.PMID 28204942Read ↗

Interpretation of XIAP Variants of Uncertain Significance in Paediatric Patients with Refractory Crohn's Disease.Semantic proximity Read ↗

“The molecule’s the thing:” the promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing resultsSemantic proximity Read ↗

Docking-based modeling of protein-protein interfaces for extensive structural and functional characterization of missense mutations.Semantic proximity Read ↗

Protein molecular modeling techniques investigating novel TAB 2 variant R347X causing cardiomyopathy and congenital heart defects in multigenerational familySemantic proximity Read ↗

An Integrated Computational Framework to Assess the Mutational Landscape of α-L-Iduronidase IDUA Gene.Semantic proximity Read ↗

PHIP gene variants with protein modeling, interactions, and clinical phenotypes.Semantic proximity Read ↗

Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel diseaseSemantic proximity Read ↗

The conformational and mutational landscape of the ubiquitin-like marker for autophagosome formation in cancer.Semantic proximity Read ↗

Structural and functional consequences of non-synonymous SNPs within the LAMA2 protein: a molecular dynamics perspective.Semantic proximity Read ↗

An In Silico Analysis of Genetic Variants and Structural Modeling of the Human Frataxin Protein in Friedreich's Ataxia.Semantic proximity Read ↗

Modeling and analyzing three-dimensional structures of human disease proteins.Semantic proximity Read ↗

Using an integrative machine learning approach utilising homology modelling to clinically interpret genetic variants: CACNA1F as an exemplar.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.