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Article

Intergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures.

EBioMedicine - 1 Mar 2017

Wu Dengchang, Feng Bo, Dai Yunjian, Wu Xiaohua, Chen Bin, Xu Cenglin, Tang Yangshun, Wang Kang, Zhang Shihong, Wang Shuang, Luo Benyan, Chen Zhong

Abstract excerpt

Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future offspring, even if the offspring never experience febrile seizures. This transgenerational...

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Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Rats, Sprague-Dawley

Share to Seizures, Febrile

Source

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Identifiers

PMID: 28202230
DOI: 10.1016/j.ebiom.2017.02.006
PMCID: PMC5360568

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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