Article
Association Between the Probability of Autism Spectrum Disorder and Normative Sex-Related Phenotypic Diversity in Brain Structure.
JAMA psychiatry - 1 Apr 2017
Ecker Christine, Andrews Derek S, Gudbrandsen Christina M, Marquand Andre F, Ginestet Cedric E, Daly Eileen M, Murphy Clodagh M, Lai Meng-Chuan, Lombardo Michael V, Ruigrok Amber N V, Bullmore Edward T, Suckling John, Williams Steven C R, Baron-Cohen Simon, Craig Michael C, Murphy Declan G M
Abstract excerpt
Importance: Autism spectrum disorder (ASD) is 2 to 5 times more common in male individuals than in female individuals. While the male preponderant prevalence of ASD might partially be explained by sex differences in clinical symptoms, etiological models suggest that the biological male phenotype carries a higher intrinsic risk for ASD than the female phenotype. To our knowledge, this hypothesis has never been...
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