Article
Can the "female protective effect" liability threshold model explain sex differences in autism spectrum disorder?
Neuron - 19 Oct 2022
Dougherty Joseph D, Marrus Natasha, Maloney Susan E, Yip Benjamin, Sandin Sven, Turner Tychele N, Selmanovic Din, Kroll Kristen L, Gutmann David H, Constantino John N, Weiss Lauren A
Abstract excerpt
Male sex is a strong risk factor for autism spectrum disorder (ASD). The leading theory for a "female protective effect" (FPE) envisions males and females have "differing thresholds" under a "liability threshold model" (DT-LTM). Specifically, this model posits that females require either a greater number or larger magnitude of risk factors (i.e., greater liability) to manifest ASD, which is supported by the...
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