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Article

Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation.

JCI insight - 19 Oct 2017

Howles Sarah A, Hannan Fadil M, Gorvin Caroline M, Piret Sian E, Paudyal Anju, Stewart Michelle, Hough Tertius A, Nesbit M Andrew, Wells Sara, Brown Stephen Dm, Cox Roger D, Thakker Rajesh V

Abstract excerpt

Loss-of-function mutations of GNA11, which encodes G-protein subunit α11 (Gα11), a signaling partner for the calcium-sensing receptor (CaSR), result in familial hypocalciuric hypercalcemia type 2 (FHH2). FHH2 is characterized by hypercalcemia, inappropriately normal or raised parathyroid hormone (PTH) concentrations, and normal or low urinary calcium excretion. A mouse model for FHH2 that would facilitate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gq-G11

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Source

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Identifiers

PMID: 29046478
DOI: 10.1172/jci.insight.96540
PMCID: PMC5846897

Genes

PTH
GNA11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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