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Article

A Variant in COX-2 Gene Is Associated with Left Main Coronary Artery Disease and Clinical Outcomes of Coronary Artery Bypass Grafting.

BioMed research international - 1 Jan 2017

Liu Hanning, Xu Zhengxi, Sun Cheng, Gu Dachuan, Teng Xiao, Zhao Yan, Zheng Zhe

Abstract excerpt

As a particular severe phenotype of coronary artery disease (CAD), left main coronary artery disease (LMCAD) is heritable. Genetic variants related to prostaglandin metabolism are associated with LMCAD. Cyclooxygenase-2 (COX-2), a key synthase in prostaglandin pathways, displays high density in atherosclerotic lesions and promotes early atherosclerosis in CAD progression. We hypothesized that genetic variants in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28194409
DOI: 10.1155/2017/2924731
PMCID: PMC5286485

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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