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[Association of common cyclooxygenase-2 (COX-2) gene polymorphisms with clinical and angiographic characteristics of patients with coronary artery disease].

Przeglad lekarski - 1 Jan 2014

Rostoff Pawel, Szczeklik Wojciech, Piwowarska Wieslawa, Konduracka Ewa, Sanak Marek, Nessler Jadwiga

Abstract excerpt

BACKGROUND: Chronic inflammation of the arterial wall plays a crucial role in the pathogenesis of atherosclerosis. Cyclooxygenase-2 (COX-2) is a key enzyme in the synthesis of proinflammatory prostanoids. At least two of the common genetic polymorphisms of the COX-2 gene have phenotypic effects: G-765C (rs20417) and T8473C (rs5275). AIM: To assess the relation of G-765C and T8473C COX-2 polymorphisms to clinical...

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PMID: 25344971

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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