Article
Identification of ANGPT2 as a New Gene for Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the Chinese and Japanese Populations.
Investigative ophthalmology & visual science - 1 Feb 2017
Ma Li, Brelen Marten E, Tsujikawa Motokazu, Chen Haoyu, Chu Wai Kit, Lai Timothy Y Y, Ng Danny S C, Sayanagi Kaori, Hara Chicako, Hashida Noriyasu, Chan Vesta C K, Tam Pancy O S, Young Alvin L, Chen Weiqi, Nishida Kohji, Pang Chi Pui, Chen Li Jia
Abstract excerpt
Purpose: We determine the angiopoietin 2 (ANGPT2) gene as a new susceptibility gene for neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV). Methods: A total of 34 haplotype-tagging single-nucleotide polymorphisms (SNPs) were first genotyped in an exploratory Hong Kong Chinese cohort. Suggestive SNPs were replicated in a Shantou Chinese cohort and an Osaka Japanese...
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