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Article

BlackOPs: increasing confidence in variant detection through mappability filtering.

Nucleic acids research - 1 Oct 2013

Cabanski Christopher R, Wilkerson Matthew D, Soloway Matthew, Parker Joel S, Liu Jinze, Prins Jan F, Marron J S, Perou Charles M, Hayes D Neil

Abstract excerpt

Identifying variants using high-throughput sequencing data is currently a challenge because true biological variants can be indistinguishable from technical artifacts. One source of technical artifact results from incorrectly aligning experimentally observed sequences to their true genomic origin ('mismapping') and inferring differences in mismapped sequences to be true variants. We developed BlackOPs, an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23935067
DOI: 10.1093/nar/gkt692
PMCID: PMC3799449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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