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Article

Complement-mediated thrombotic microangiopathy associated with lupus nephritis.

Blood advances - 28 Aug 2018

Park Mi Hee, Caselman Nicholas, Ulmer Scott, Weitz Ilene Ceil

Abstract excerpt

Complement-mediated thrombotic microangiopathy (CM-TMA) is a clinical disorder driven by the generation of excess complement. It is characterized by thrombocytopenia and microangiopathic hemolytic anemia (MAHA) with microvascular thrombosis resulting in systemic organ damage (TMA). One form of CM-TMA, atypical hemolytic uremic syndrome (aHUS), is characterized by pathologic complement activation due to the loss...

Topics

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Complement system in diseases
Complement System Proteins
CFH gene
Lupus Nephritis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Renal Diseases and Glomerulopathies

Systemic Lupus Erythematosus Research

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Open in PubMed Open full text

Identifiers

PMID: 30131343
DOI: 10.1182/bloodadvances.2018019596
PMCID: PMC6113612

Genes

CFH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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