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Article

Probing the molecular determinants of fluorinase specificity.

Chemical communications (Cambridge, England) - 23 Feb 2017

Yeo W L, Chew X, Smith D J, Chan K P, Sun H, Zhao H, Lim Y H, Ang E L

Abstract excerpt

Molecular determinants of FlA1 fluorinase specificity were probed using 5'-chloro-5'-deoxyadenosine (5'-ClDA) analogs as substrates and FlA1 active site mutants. Modifications at F213 or A279 residues are beneficial towards these modified substrates, including 5'-chloro-5'-deoxy-2-ethynyladenosine, ClDEA (>10-fold activity improvement), and conferred novel activity towards substrates not readily accepted by...

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PMID: 28184383
DOI: 10.1039/c6cc09213f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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