The Lineage Specification of Mesenchymal Stem Cells Is Directed by the Rate of Fluid Shear Stress.

doi:10.1002/jcp.25278

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Article

The Lineage Specification of Mesenchymal Stem Cells Is Directed by the Rate of Fluid Shear Stress.

Journal of cellular physiology - 1 Aug 2016

Lu Juan, Fan Yijuan, Gong Xiaoyuan, Zhou Xin, Yi Caixia, Zhang Yinxing, Pan Jun

Abstract excerpt

The effective regulation of fluid shear stress (FSS) on the lineage specification of mesenchymal stem cells (MSCs) remains to be addressed. We hypothesized that when MSCs are recruited to musculoskeletal system following stimulation, their differentiation into osteogenic or chondrogenic cells is directed by the rate of FSS (ΔSS) through modulation of the mechanosensitive, cation-selective channels (MSCCs),...

Topics

Actins
Alkaline Phosphatase
Animals
Biomarkers
Calcium
Calcium Channels
Calcium Signaling
Cell Differentiation
Cell Lineage
Cells, Cultured
Chondrocytes
Chondrogenesis
Glycosaminoglycans
Male
Mechanotransduction, Cellular

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PMID: 26636289
DOI: 10.1002/jcp.25278

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Mesenchymal Stem Cells

Nitric Oxide

Osteoblasts