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Impact of Grade on Survival in Pleomorphic Xanthoastrocytoma and Low Prevalence of BRAF V600E Mutation.

World neurosurgery - 1 Aug 2022

Gandham Edmond Jonathan, Goyal-Honavar Abhijit, Beno Daniel, Pai Rekha, Balakrishan Rajesh, Jasper Anita, Gowri Mahasampath, Moorthy Ranjith K, Chacko Ari George, Chacko Geeta

Abstract excerpt

BACKGROUND: The prevalence of BRAFV600E mutations in pleomorphic xanthoastrocytoma (PXA) World Health Organization (WHO) Grade 2 and PXA WHO Grade 3 reported varies from 60% to 80%, yet the prognostic implications remain unclear. METHODS: We reviewed the demographic and clinicoradiologic data of 20 PXAs WHO Grade 2 and 13 PXAs WHO Grade 3, operated between 2007 and 2020, to ascertain extent of excision,...

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PMID: 35618235
DOI: 10.1016/j.wneu.2022.05.066

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