Article
Cytochrome P450 Genetic Variations Can Predict mRNA Expression, Cyclophosphamide 4-Hydroxylation, and Treatment Outcomes in Chinese Patients With Non-Hodgkin's Lymphoma.
Journal of clinical pharmacology - 1 Jul 2017
Shu Wenying, Chen Lingyan, Hu Xiaoye, Zhang Meimei, Chen Wensheng, Ma Lei, Liu Xiaoyan, Huang Jianing, Pang Tingyuan, Li Jia, Zhang Yu
Abstract excerpt
To investigate the impact of cytochrome P450 (CYP) genetic polymorphisms CYP2B6, CYP2C19, and CYP3A5 on mRNA expression, cyclophosphamide/4-hydroxycyclophosphamide pharmacokinetics, and treatment outcomes of the R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) in Chinese patients with non-Hodgkin's lymphoma, 567 cases were investigated. Plasma concentrations of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.