Article
Severe and prolonged cyclophosphamide-induced hepatotoxicity in a breast cancer patient carrying a CYP2B6*7 variant.
Pharmacogenomics - 1 Nov 2019
Ming Zhao, Yongqiang Zhang, Zijin Zhang, Yan Xu, Di Chen, Xiaoxin Tian
Abstract excerpt
As a widely used alkylating agent, cyclophosphamide often leads to various toxicities. Severe hepatotoxicity has been rarely reported in breast cancer patients receiving chemotherapy containing cyclophosphamide. Differences in cyclophosphamide metabolism may contribute to variability in adverse events of patients. Here, we report on a case of a 68-year-old Chinese female with breast cancer who experienced severe...
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