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Article

Cytochrome P450 2B6*5 Increases Relapse after Cyclophosphamide-Containing Conditioning and Autologous Transplantation for Lymphoma.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 May 2015

Bachanova Veronika, Shanley Ryan, Malik Farhana, Chauhan Lata, Lamba Vishal, Weisdorf Daniel J, Burns Linda J, Lamba Jatinder Kaur

Abstract excerpt

Cyclophosphamide (Cy) is a prodrug that depends on bioactivation by hepatic cytochrome P450 (CYP) enzymes for its cytotoxicity. We evaluated the influence of single nucleotide polymorphisms (SNPs) of CYP enzymes on the efficacy of autologous hematopoietic cell transplantation (HCT) for lymphoma. SNPs of 22 genes were analyzed in 93 patients with Hodgkin (n = 52) and non-Hodgkin lymphoma (n = 41) treated with...

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Identifiers

PMID: 25677220
DOI: 10.1016/j.bbmt.2015.02.001
PMCID: PMC4772424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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