Article
Super-resolution imaging of alpha-synuclein polymorphisms and their potential role in neurodegeneration.
Integrative biology : quantitative biosciences from nano to macro - 1 Mar 2017
Nugent Eileen, Kaminski Clemens F, Kaminski Schierle Gabriele S
Abstract excerpt
The conversion of soluble, functional proteins into amyloid fibrils has been linked to the development of neurodegenerative disorders, including Parkinson's and Alzheimer's disease. In the brains of patients with these disorders, the increasing presence of amyloid-containing plaques corresponds to neuronal cell death and the worsening of symptoms. However, protein amyloids are not merely confined to dying cells....
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