Article
Identification of rare nonsynonymous variants in SYNE1/CPG2 in bipolar affective disorder.
Psychiatric genetics - 1 Jun 2017
Sharp Sally Isabel, Lange Jenny, Kandaswamy Radhika, Daher Mazen, Anjorin Adebayo, Bass Nicholas James, McQuillin Andrew
Abstract excerpt
BACKGROUND: Bipolar affective disorder (BPD) is a severe mood disorder with a prevalence of ∼1.5% in the population. The pathogenesis of BPD is poorly understood; however, a strong heritable component has been identified. Previous genome-wide association studies have indicated a region on 6q25, coding for the SYNE1 gene, which increases disease susceptibility. SYNE1 encodes the synaptic nuclear envelope...
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