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Article

Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival.

Infection and immunity - 1 Apr 2017

McPeak Melissa B, Youssef Dima, Williams Danielle A, Pritchett Christopher, Yao Zhi Q, McCall Charles E, El Gazzar Mohamed

Abstract excerpt

Myeloid progenitor-derived suppressor cells (MDSCs) arise from myeloid progenitors and suppress both innate and adaptive immunity. MDSCs expand during the later phases of sepsis in mice, promote immunosuppression, and reduce survival. Here, we report that the myeloid differentiation-related transcription factor nuclear factor I-A (NFI-A) controls MDSC expansion during sepsis and impacts survival. Unlike MDSCs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28167668
DOI: 10.1128/IAI.00066-17
PMCID: PMC5364314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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