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Article

ITPase activity modulates the severity of anaemia in HCV-related cirrhosis treated with ribavirin-containing interferon-free regimens.

Antiviral therapy - 1 Jan 2017

Coppola Nicola, De Pascalis Stefania, Messina Vincenzo, Di Caprio Giovanni, Martini Salvatore, de Stefano Giorgio, Starace Mario, Stornaiuolo Gianfranca, Stanzione Maria, Ascione Tiziana, Minichini Carmine, Sangiovanni Vincenzo, Zampino Rosa, Calò Federica, Rinaldi Luca, Persico Marcello, Federico Alessandro, Buonomo Antonio Riccardo, Borgia Guglielmo, Gaeta Giovanni Battista, Filippini Pietro, Gentile Ivan

Abstract excerpt

BACKGROUND: To investigate the association between inosine triphosphatase (ITPase) activity and the degree of anaemia occurring during direct-acting antiviral (DAA)/ribavirin (RBV)-based therapy in patients with cirrhosis. METHODS: In a multicentre, prospective study 227 patients with HCV-related cirrhosis treated with DAA and RBV were enrolled. All patients were screened for the rs1127354 and rs7270101 ITPA...

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Topics

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Share to Anemia
Share to Disease Susceptibility
Share to Drug Therapy, Combination
Share to Enzyme Activation
Share to Hepatitis C, Chronic
Share to Liver Cirrhosis
Share to Pyrophosphatases
Share to Ribavirin

Source

Identifiers

PMID: 28165327
DOI: 10.3851/IMP3134

Genes

ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ITPase activity modulates the severity of anaemia in HCV-related cirrhosis treated with ribavirin-containing interferon-free regimens.PMID 28165327Read ↗

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