Article
HER2 exon 27 mutations predict worse survival of breast cancer patients, especially in HER2-negative patients.
Cancer medicine - 1 Dec 2017
Si Pilei, Chen Tao, Fang Bin, Yao Jiabing, Liu Gaoxiu, Chen Haijun, Zhai Baoping, Li Wentao
Abstract excerpt
The aims of this study were to assess the prognostic value of the HER2 exon 27 mutations in breast cancer patients. Genomic DNA was isolated from peripheral blood leukocytes, and then HER2 exon 27 mutations were detected by direct sequencing. Survival curves were estimated by Kaplan-Meier curves and the differences between the curves were compared by log-rank tests. A total cohort of 892 female patients with...
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