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Article

Activation of a Plant NLR Complex through Heteromeric Association with an Autoimmune Risk Variant of Another NLR.

Current biology : CB - 24 Apr 2017

Tran Diep T N, Chung Eui-Hwan, Habring-Müller Anette, Demar Monika, Schwab Rebecca, Dangl Jeffery L, Weigel Detlef, Chae Eunyoung

Abstract excerpt

When independently evolved immune receptor variants meet in hybrid plants, they can activate immune signaling in the absence of non-self recognition. Such autoimmune risk alleles have recurrently evolved at the DANGEROUS MIX2 (DM2) nucleotide-binding domain and leucine-rich repeat (NLR)-encoding locus in A. thaliana. One of these activates signaling in the presence of a particular variant encoded at another NLR...

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Identifiers

PMID: 28416116
DOI: 10.1016/j.cub.2017.03.018
PMCID: PMC5405217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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