IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry.

doi:10.1038/srep41920

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IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry.

Scientific reports - 3 Feb 2017

Sanabria-Salas María Carolina, Hernández-Suárez Gustavo, Umaña-Pérez Adriana, Rawlik Konrad, Tenesa Albert, Serrano-López Martha Lucía, Sánchez de Gómez Myriam, Rojas Martha Patricia, Bravo Luis Eduardo, Albis Rosario, Plata José Luis, Green Heather, Borgovan Theodor, Li Li, Majumdar Sumana, Garai Jone, Lee Edward, Ashktorab Hassan, Brim Hassan, Li Li, Margolin David, Fejerman Laura, Zabaleta Jovanny

Abstract excerpt

Single-nucleotide polymorphisms (SNPs) in cytokine genes can affect gene expression and thereby modulate inflammation and carcinogenesis. However, the data on the association between SNPs in the interleukin 1 beta gene (IL1B) and colorectal cancer (CRC) are conflicting. We found an association between a 4-SNP haplotype block of the IL1B (-3737C/-1464G/-511T/-31C) and CRC risk, and this association was exclusively...

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PMID: 28157220
DOI: 10.1038/srep41920
PMCID: PMC5291207

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