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Article

DDX53 Promotes Cancer Stem Cell-Like Properties and Autophagy

1 Jan 2017

Abstract excerpt

and LC-3I/II compared with MCF-7. DDX53 regulated the expression of marker proteins of autophagy in MCF-7 and MDA-MB-231 cells. miR-200b and miR-217 negatively regulated the expression of autophagy marker proteins. Chromatin immunoprecipitation assays showed the direct regulation of ATG-5. The decreased expression of ATG-5 by siRNA increased the sensitivity to anti-cancer drugs in MDA-MB-231 cells. In conclusion,...

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Identifiers

PMID: 28152297
DOI: 10.14348/molcells.2017.2258

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