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Article

Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer.

Cell cycle (Georgetown, Tex.) - 18 Apr 2017

Zhang Le, Xu Liang, Zhang Fengchun, Vlashi Erina

Abstract excerpt

Experimental evidence suggest that breast tumors originate from breast cancer stem cells (BCSCs), and that mitochondrial biogenesis is essential for the anchorage-independent clonal expansion and survival of CSCs, thus rendering mitochondria a significant target for novel treatment approaches. One of the recognized side effects of the FDA-approved drug, doxycycline is the inhibition of mitochondrial biogenesis....

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Identifiers

PMID: 27753527
DOI: 10.1080/15384101.2016.1241929
PMCID: PMC5405729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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