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Article

Exploitation of the Toll-like receptor system in cancer: a doubled-edged sword?

1 Aug 2006

Abstract excerpt

The toll-like receptor (TLR) system constitutes a pylogenetically ancient, evolutionary conserved, archetypal pattern recognition system, which underpins pathogen recognition by and activation of the immune system. Toll-like receptor agonists have long been used as immunoadjuvants in anti cancer immunotherapy. However, TLRs are increasingly implicated in human disease pathogenesis and an expanding body of both...

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PMID: 16892041
DOI: 10.1038/sj.bjc.6603275

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