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Article

TET1 promotes cisplatin‐resistance via demethylating the vimentin promoter in ovarian cancer

2 Feb 2017

Abstract excerpt

The development of chemo-resistance impairs the outcome of the first line platinum-based chemotherapies for ovarian cancer. Deregulation of DNA methylation/demethylation provides a critical mechanism for the occurrence of chemo-resistance. The ten-eleven translocation (TET) family of dioxygenases including TET1/2/3 plays an important part in DNA demethylation, but their roles in cisplatin resistance have not been...

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PMID: 28150354
DOI: 10.1002/cbin.10734

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