Article
Frequent low-level mutations of protein kinase D2 in angiolipoma.
The Journal of pathology - 1 Apr 2017
Hofvander Jakob, Arbajian Elsa, Stenkula Karin G, Lindkvist-Petersson Karin, Larsson Malin, Nilsson Jenny, Magnusson Linda, von Steyern Fredrik Vult, Rissler Pehr, Hornick Jason L, Mertens Fredrik
Abstract excerpt
Tumours displaying differentiation towards normal fat constitute the most common subgroup of soft tissue neoplasms. A series of such tumours was investigated by whole-exome sequencing followed by targeted ultra-deep sequencing. Eighty per cent of angiolipomas, but not any other tumour type, displayed mutations in the protein kinase D2 (PRKD2) gene, typically in the part encoding the catalytic domain. The absence...
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