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Article

TSC2 inactivation, low mutation burden and high macrophage infiltration characterise hepatic angiomyolipomas.

Histopathology - 1 Oct 2023

Giannikou Krinio, Klonowska Katarzyna, Tsuji Junko, Wu Shulin, Zhu Zachary, Probst Clemens K, Kao Katrina Z, Wu Chin-Lee, Rodig Scott, Marino-Enriquez Adrian, Zen Yoh, Schaefer Inga-Marie, Kwiatkowski David J

Abstract excerpt

AIMS: Although TSC1 or TSC2 inactivating mutations that lead to mTORC1 hyperactivation have been reported in hepatic angiomyolipomas (hAML), the role of other somatic genetic events that may contribute to hAML development is unknown. There are also limited data regarding the tumour microenvironment (TME) of hAML. The aim of the present study was to identify other somatic events in genomic level and changes in TME...

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PMID: 37679051
DOI: 10.1111/his.15005

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