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Article

Genomic landscape and molecular evolutionary trajectories of renal epithelioid angiomyolipoma and benign angiomyolipoma.

Neoplasia (New York, N.Y.) - 1 Oct 2025

Anwaier Aihetaimujiang, Qu Yuanyuan, Ye Shiqi, Tian Xi, Zhu Shuxuan, Zhou Siqi, Shi Guohai, Zhu Yu, Zhang Hailiang, Ye Dingwei, Xu Wenhao

Abstract excerpt

Renal angiomyolipoma (AML) encompasses benign variants (lipomatous [L-AML], myomatous [M-AML]) and epithelioid AML (eAML), a potentially malignant subtype associated with aggressive behavior. While TSC1/TSC2 mutations are frequent, the molecular drivers underlying eAML pathogenesis remain unclear. Whole-exome sequencing (WES) was performed on 35 AML samples (15 eAML, 10 L-AML, 10 M-AML) with matched germline...

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Identifiers

PMID: 40706452
DOI: 10.1016/j.neo.2025.101212
PMCID: PMC12446979

Genes

TSC2
POLDIP2
MUC2
NEFH
ASXL1
RHPN2
TOP3B
TSC1
USP35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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