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A proteomic analysis unravels novel CORVET and HOPS proteins involved in Toxoplasma gondii secretory organelles biogenesis.

Cellular microbiology - 1 Nov 2018

Morlon-Guyot Juliette, El Hajj Hiba, Martin Kevin, Fois Adrien, Carrillo Amandine, Berry Laurence, Burchmore Richard, Meissner Markus, Lebrun Maryse, Daher Wassim

Abstract excerpt

Apicomplexans use the endolysosomal system for the biogenesis of their secretory organelles, namely, micronemes, rhoptries, and dense granules. In Toxoplasma gondii, our previous in silico search identified the HOPS tethering but not the CORVET complex and demonstrated a role of Vps11 (a common component for both complexes) in its secretory organelle biogenesis. Herein, we performed Vps11-GFP-Trap pull-down...

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PMID: 29911335
DOI: 10.1111/cmi.12870

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