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Article

Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection.

Nature communications - 11 Apr 2016

Sangaré Lamba Omar, Alayi Tchilabalo Dilezitoko, Westermann Benoit, Hovasse Agnes, Sindikubwabo Fabien, Callebaut Isabelle, Werkmeister Elisabeth, Lafont Frank, Slomianny Christian, Hakimi Mohamed-Ali, Van Dorsselaer Alain, Schaeffer-Reiss Christine, Tomavo Stanislas

Abstract excerpt

Membrane trafficking pathways play critical roles in Apicomplexa, a phylum of protozoan parasites that cause life-threatening diseases worldwide. Here we report the first retromer-trafficking interactome in Toxoplasma gondii. This retromer complex includes a trimer Vps35-Vps26-Vps29 core complex that serves as a hub for the endosome-like compartment and parasite-specific proteins. Conditional ablation of TgVps35...

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Identifiers

PMID: 27064065
DOI: 10.1038/ncomms11191
PMCID: PMC4831018

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