Article

Unexpected D-tour Ahead: Why the D-Statistic, applied to Humans, Measures Mutation Rate Variation not Neanderthal Introgression

2025-01-01

Abstract excerpt

It is widely accepted that humans interbred with Neanderthals and other extinct hominins, leaving a lasting genetic legacy. However, much of the supporting evidence was developed using the statistic D, which assumes, without testing, both that mutation rate is constant and that recurrent mutations are vanishingly rare. These assumptions together preclude an alternative explanation based on variation in mutation ra...

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Literature Corpus work: a380d09a-669a-567a-b8b2-2892ec544c42
DOI: 10.1101/2024.12.31.630954

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