Article
Some Synonymous and Nonsynonymous gyrA Mutations in Mycobacterium tuberculosis Lead to Systematic False-Positive Fluoroquinolone Resistance Results with the Hain GenoType MTBDRsl Assays.
Antimicrobial agents and chemotherapy - 1 Apr 2017
Ajileye Adebisi, Alvarez Nataly, Merker Matthias, Walker Timothy M, Akter Suriya, Brown Kerstin, Moradigaravand Danesh, Schön Thomas, Andres Sönke, Schleusener Viola, Omar Shaheed V, Coll Francesc, Huang Hairong, Diel Roland, Ismail Nazir, Parkhill Julian, de Jong Bouke C, Peto Tim E A, Crook Derrick W, Niemann Stefan, Robledo Jaime, Smith E Grace, Peacock Sharon J, Köser Claudio U
Abstract excerpt
In this study, using the Hain GenoType MTBDRsl assays (versions 1 and 2), we found that some nonsynonymous and synonymous mutations in gyrA in Mycobacterium tuberculosis result in systematic false-resistance results to fluoroquinolones by preventing the binding of wild-type probes. Moreover, such mutations can prevent the binding of mutant probes designed for the identification of specific resistance mutations....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.