Performance of the genotype MTBDR line probe assay for detection of resistance to rifampin and isoniazid in strains of Mycobacterium tuberculosis with low- and high-level resistance.

Abstract excerpt

We assessed the performance of the Genotype MTBDR line probe assay that offers the simultaneous identification of Mycobacterium tuberculosis and its resistance to rifampin (RIF) and isoniazid (INH) by detecting the most commonly found mutations in the rpoB and katG genes. One hundred thirteen M. tuberculosis isolates were tested. The nucleotide sequences of the katG and inhA genes and the mabA-inhA promoter...

Topics

• Antitubercular Agents
• Bacteriological Techniques
• Dose-Response Relationship, Drug
• Drug Resistance, Bacterial
• Genotype
• Isoniazid
• Mycobacterium tuberculosis
• Rifampin