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Article

Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE ε4 Genotype.

JAMA neurology - 1 Mar 2017

Krell-Roesch Janina, Vemuri Prashanthi, Pink Anna, Roberts Rosebud O, Stokin Gorazd B, Mielke Michelle M, Christianson Teresa J H, Knopman David S, Petersen Ronald C, Kremers Walter K, Geda Yonas E

Abstract excerpt

Importance: Cross-sectional associations between engagement in mentally stimulating activities and decreased odds of having mild cognitive impairment (MCI) or Alzheimer disease have been reported. However, little is known about the longitudinal outcome of incident MCI as predicted by late-life (aged ≥70 years) mentally stimulating activities. Objectives: To test the hypothesis of an association between mentally...

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Source

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Identifiers

PMID: 28135351
DOI: 10.1001/jamaneurol.2016.3822
PMCID: PMC5473779

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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