Article
G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition.
Nature structural & molecular biology - 1 Mar 2017
Sahakyan Aleksandr B, Murat Pierre, Mayer Clemens, Balasubramanian Shankar
Abstract excerpt
Long interspersed nuclear elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that have a significant role in shaping genomes, owing to their abundance. Here we report that guanine-rich sequences in the 3' untranslated regions (UTRs) of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex...
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