Article
HLA-DRA/HLA-DRB5 polymorphism affects risk of sporadic ALS and survival in a southwest Chinese cohort.
Journal of the neurological sciences - 15 Feb 2017
Yang Xinglong, Zheng JinHua, Tian Sijia, Chen Yalan, An Ran, Zhao Quanzhen, Xu Yanming
Abstract excerpt
INTRODUCTION: Frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) are neurodegenerative diseases that share common genetic risk factors. A recent genome-wide association study has linked risk of FTD with polymorphisms in the HLA-DRA/HLA-DRB5 gene (rs9268877, rs9268856), BTNL2 gene (rs1980493), and RAB38/CTSC gene (rs302668). METHODS: We used the SNPscan™ Kit to genotype...
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