Article
Association of Frontotemporal Dementia GWAS Loci with Late-Onset Alzheimer's Disease in a Northern Han Chinese Population.
Journal of Alzheimer's disease : JAD - 26 Feb 2016
Tan Chen-Chen, Wan Yu, Tan Meng-Shan, Zhang Wei, Wang Zi-Xuan, Sun Fu-Rong, Miao Dan, Tan Lan, Yu Jin-Tai
Abstract excerpt
BACKGROUND: Both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are a class of neurodegenerative diseases. Strong similarities in cerebrospinal fluid biomarker, imaging markers, and disease progression profiles suggest that some or most of the pathophysiology is shared between AD and FTD. A recent large genome-wide association study reported several single nucleotide polymorphisms (SNPs) at the RAB38,...
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