Article
Diversity of CRISPR loci in Escherichia coli.
Microbiology (Reading, England) - 1 May 2010
Díez-Villaseñor C, Almendros C, García-Martínez J, Mojica F J M
Abstract excerpt
CRISPR (clustered regularly interspaced short palindromic repeats) and CAS (CRISPR-associated sequence) proteins are constituents of a novel genetic barrier that limits horizontal gene transfer in prokaryotes by means of an uncharacterized mechanism. The fundamental discovery of small RNAs as the guides of the defence apparatus arose as a result of Escherichia coli studies. However, a survey of the system...
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