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The role of quantitative systems pharmacology modeling in the prediction and explanation of idiosyncratic drug-induced liver injury

21 Nov 2016

Abstract excerpt

Idiosyncratic drug-induced liver injury (iDILI) is a serious concern in drug development. The rarity and multifactorial nature of iDILI makes it difficult to predict and explain. Recently, human leukocyte antigen (HLA) allele associations have provided strong support for a role of an adaptive immune response in the pathogenesis of many iDILI cases; however, it is likely that an adaptive immune attack requires...

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PMID: 28129975
DOI: 10.1016/j.dmpk.2016.11.008

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