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Article

[Three-dimensional Structure of eIF2B: A Clue to Understanding the Pathogenesis of CACH/VWM Disease].

Brain and nerve = Shinkei kenkyu no shinpo - 1 Jan 2017

Kashiwagi Kazuhiro, Ito Takuhiro, Yokoyama Shigeyuki

Abstract excerpt

CACH/VWM (childhood ataxia with central nervous system hypomyelination/vanishing white matter) disease is caused by mutations in the genes encoding the subunits of eukaryotic initiation factor 2B (eIF2B), but its etiology is poorly understood. Here, we attempt to provide an explanation for the pathogenic mechanism of this disease, based on the crystal structure of eIF2B.

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Source

Identifiers

PMID: 28126977
DOI: 10.11477/mf.1416200635

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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