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Article

The large spectrum of eIF2B-related diseases.

Biochemical Society transactions - 1 Feb 2006

Fogli A, Boespflug-Tanguy O

Abstract excerpt

eIF2B (eukaryotic initiation factor 2B) is a GEF (guanine nucleotide-exchange factor) that plays, with its substrate eIF2, a key regulatory role in the translation initiation phase of protein synthesis. The importance of correct control of eIF2 and eIF2B for normal physiology is underlined by the recent involvement of the five genes that encode the five eIF2B subunits in a severe autosomal recessive...

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Identifiers

PMID: 16246171
DOI: 10.1042/BST20060022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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