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[Eukaryotic translation initiation factor 2B and leukoencephalopathy with vanishing white matter].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences - 18 Oct 2009

Pan Yan Xia, Wu Ye, Niu Zheng Ping, Jiang Yu Wu

Abstract excerpt

Leukoencephalopathy with vanishing white matter (VWM) is one of the most prevalent inherited white matter disorders in childhood, and it's the only known hereditary human disease due to the direct defects in protein synthesis process, with the gene defects in EIF2B1-5, encoding the five subunits of eukaryotic translation initiation factor (eIF2B alpha, beta, gamma, delta and epsilon ) respectively. eIF2B is...

Topics

Eukaryotic Initiation Factor-2B
Humans
Leukoencephalopathies
Mutation
Protein Biosynthesis
Transcription Factors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19829687

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