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Article

Gleason Score 7 Prostate Cancers Emerge through Branched Evolution of Clonal Gleason Pattern 3 and 4.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2017

Sowalsky Adam G, Kissick Haydn T, Gerrin Sean J, Schaefer Rachel J, Xia Zheng, Russo Joshua W, Arredouani M Simo, Bubley Glenn J, Sanda Martin G, Li Wei, Ye Huihui, Balk Steven P

Abstract excerpt

Purpose: The molecular features that account for the distinct histology and aggressive biological behavior of Gleason pattern 4 (Gp4) versus Gp3 prostate cancer, and whether Gp3 tumors progress directly to Gp4, remain to be established.Experimental Design: Whole-exome sequencing and transcriptome profiling of laser capture-microdissected adjacent Gp3 and cribiform Gp4 were used to determine the relationship...

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Identifiers

PMID: 28119368
DOI: 10.1158/1078-0432.CCR-16-2414
PMCID: PMC5511561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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