Article

Dysregulation of the PRUNE2/PCA3 genetic axis in human prostate cancer: From experimental discovery to validation in two independent patient cohorts

2022-10-30

Abstract excerpt

<h4>BACKGROUND</h4> We have previously shown that the long non-coding (lnc)RNA prostate cancer associated 3 ( PCA3 ; formerly prostate cancer antigen 3 ) functions as a trans-dominant negative oncogene by targeting the previously unrecognized prostate cancer suppressor gene PRUNE2 (a homolog of the Drosophila prune gene), thereby forming a functional unit within a unique allelic locus in human cells. Here we...

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Literature Corpus work: 7b4ffe3c-7fa7-5b3e-a4c1-acbddd231d0b
DOI: 10.1101/2022.10.25.22281522

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