Article
A systematic SNP selection approach to identify mechanisms underlying disease aetiology: linking height to post-menopausal breast and colorectal cancer risk.
Scientific reports - 24 Jan 2017
Elands Rachel J J, Simons Colinda C J M, Riemenschneider Mona, Isaacs Aaron, Schouten Leo J, Verhage Bas A, Van Steen Kristel, Godschalk Roger W L, van den Brandt Piet A, Stoll Monika, Weijenberg Matty P
Abstract excerpt
Data from GWAS suggest that SNPs associated with complex diseases or traits tend to co-segregate in regions of low recombination, harbouring functionally linked gene clusters. This phenomenon allows for selecting a limited number of SNPs from GWAS repositories for large-scale studies investigating shared mechanisms between diseases. For example, we were interested in shared mechanisms between adult-attained...
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