Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP3Receptors in the Induction of Hyperalgesic Priming

Abstract excerpt

Hyperalgesic priming, a model of pain chronification in the rat, is mediated by ryanodine receptor-dependent calcium release. Although ryanodine induces priming in both sexes, females are 5 orders of magnitude more sensitive, by an estrogen receptor α (EsRα)-dependent mechanism. An inositol 1,4,5-triphosphate (IP3) receptor inhibitor prevented the induction of priming by ryanodine. For IP3induced priming, females...

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